Standard Treatment Palliative surgical bypass , bile drainage procedures (see "Palliation" section). • Chemotherapy ( see Stages II and III ) and pain-relieving procedures are standard treatments. Clinical chemotherapy trials should be considered. • Combination chemotherapy with SMF (streptozocin + mitomycin-C + 5-fluorouracil), which has a 30 to 45 percent response rate, FAM (5-fluorouracil + doxorubicin + mitomycin-C) or 5-fluorouracil + leucovorin . Three-Year Survival Less than 1 percent Palliation Eighty percent of pancreatic cancer patients have jaundice caused by an obstruction. A surgically created bypass from the gall bladder or the common bile duct to the intestine may be helpful.